第6回 脳神経外科と漢方研究会

特別講演

今回の特別講演
テキサス大学漢方研究所所長  萩野 信義  先生

"UNDERSTANDING OF TRADITIONAL KAMPO THERAPY IN BRAIN DISEASES"
 と題しての講演であった。講演要旨をここに掲載する。

特別講演       

"UNDERSTADING OF TRADITIONAL KAMPO THERAPY IN BRAIN DISEASES"

Nobuyoshi Hagino,M.D,Ph.D. Medicine, Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Professor and 
Director of Laboratory of Kampo Curl Dr., San Antonio, Texas 78284,USA

1.Balance of Kampo therapy on neurons(Yin-Yang theory).

Toki-Shakuyaku-San(TSS) is complex and combined medicinal plants and Contains peony root, atractylodes lancea rhizome, alisma rhizome, hoelen, cnidium rhizome and angelica root. Either 0.05 or 0.005 mg/ml of TSS extract in water are applied to cultured medium and following experiments are performed.Activation of nicotine acetylcholine receptors (nAchRs) by TSS facilitates Ca+2 ion flux. The active compounds are AT-6 and AT-7 of atractylodin in atractylodes lancea rhizome and they activate nAchRs, but not stimulate synthesis and release of acetylcholine. An increased intracellular Ca+2 ions seem to provide a signal for β-eudesmol of atractylodes lancea rhizome to activate intracellular K+ ions. K+ ions inactivate nAchRs and thus intervenes in Ca+2 ion flux, because excess Ca+2 ions are neurotoxin. Moreover, NMDA receptors in a lower concentration of K+ ions extracellular space (Oketsu symptom)exhibit lower activity and it leads to apoptosis of neurons, however, TSS stimulates NMDA receptors and facilitates Ca+2 ion flux, and thus intervenes in apoptosis of neurons. Furthermore, glutamate stimulates NMDA receptors and increases both Ca+2 ion flux and water flux, and thus leads to necrosis of neurons, however,TSS inactivates glutamate stimulated NMDA receptors and blocks both Ca+2 ion flux and water flux, and thus intervenes in necrosis of neurons.

2.Setting of Kampo therapy according to therapeutic context
(constitution: shou).

The capillaries in the brain with Alzheimer's disease show Oketsu symptom with lower concentration of glucose transport protein-1 (Glut-1) in the endothelial cells of B.B.B. (weak constitution: kyo-shou). Orally administered TSS reaches a peak in blood within 15-30 minutes and remains in circulation for 4-6 hrs.
Treatment with TSS improves Oketsu symptom and it improves cognitive and non-cognitive symptoms in Alzheimer patients. The capillaries in the brain with stroke show a narrowing of lumen, but not show Oketsu symptom. However, the endothelial cells of B.B.B. show an elevation of Glut-1 (strong constitution: jitus-shou). Orengedoku-to has therapeutic efficacy for treatment of stroke symptom in man, even though TSS intervenes in necrosis of neurons.

The study was supported by Grant from Tsumura & Co.,Tokyo,Japan